The Bochet group
Organic synthesis and photochemistry




 Contact info

Department of chemistry
Chemin du Musee 9
CH-1700 Fribourg
Tel.: +41-(0)26-300 8758
Fax: +41-(0)26-300 9738
christian.bochet (at)



- Kastrati, A; Bochet, C.G.; A Photochemical Amplifier Based on Self-Immolative Spacers, J. Org. Chem. 2019 (in press).

- Nkot, J.L.; Bikobo, D.S.N.; Zintchem, A.A.A.; Nyemeck, N.M.; Ndedi, E.D.M., Dihoue, P.H.B.; Pegnyemb, D.E.; Bochet, C.G.; Koert, U. Antitubercular evaluation of root extract and isolated phytochemicals from Lophira lanceolata against two resistant strains of Mycobacterium tuberculosis, Pharmaceutical Biology 2018, 56, 318-324.

- Bielmann, A.; Sambiagio, N.; Wehr, N.; Gerber-Lemaire, S.; Bochet, C.G.; Curty, C., Synthesis of different Gluthathione-Sulfur Mustard Adducts of Verified and Potential Biomarkers. RSC Advances, 2018,8, 23881-23890.

- Remy, R.; Bochet, C.G. Application of Photoclick Chemistry for the Synthesis of Pyrazoles via 1,3-Dipolar Cycloaddition between Alkynes and Nitrilimines Generated in Situ, Eur. J. Org. Chem. 2018, 316-328.

- Evina, J.N.; Bikobo, D.S.N.; Zintchem, A.A.A.; Nyemeck, N.M.; Ndedi, E.D.M., Dihoue, P.H.B.; Nyegue, M.A.; Atchade, A.D.; Pegnyemb, D.E.; Koert, U.; Bochet, C.G.  In vitro antitubercular activity of extract and constituents from the stem bark of Disthemonanthus benthamianus, Brazilian Journal of Pharmacognosy 2017, 27, 793-743.

- Bielmann, A.; Curty, C.; Bochet, C.G., Solid-phase Synthesis of the Aged-Nonapeptide-Nerve-Agent Adduct of Butyrylcholinesterase as Reference Materials for Analytical Verification, Helv. Chim. Acta 2017, 100, e1700198.

- Alimi, I.; Remy, R.; Bochet, C.G., Photochemical C-H activation: generation of indole and carbazole libraries, and first total synthesis of Clausenawalline D, Eur. J. Org. Chem. 2017, 3197-3210.

- Nyemeck II, N. M.; Ngono Bikobo, D.S.; Zintchem, A.A.A.; Schäfer, E.M.; Bochet, C. G.; Pegnyemb, D. E.; Koert, U., A new procyanidin B from Campylospermum zenkeri (Ochnaceae) and antiplasmodial activity of two derivatives of (±)-serotobenine, Nat. Prod. Res. 2017, 1-10.

- Balmer, D.; Bapst-Wicht, L.; Pyakurel, A.; Emery, M.; Nanchen, N.; Bochet, C.G.; Roduit, R., Bis-retinoid A2E Induces an Increase of basic Fibroblast Growth Factor via Inhibition of Extracellular signal-Regulated Kinases 1/2 Pathway in Retinal Pigment Epithelium Cells and Facilitates Phagocytosis, Front. Aging. Neurosci. 2017, 9(43), 1-12.

- Chetioui, S.; Rouag, D.A.; Djukic, J.P.; Bochet, C.G.; Touzani, R.; Bailly, C.; Crochet, A.; Fromm, K.M., Crystal structures of a copper(II) and the isotypic nickel(II) and palladium(II) complexes of the ligand (E)-1-[(2,4,6-tribromophenyl)diazenyl]naphthalen-2-ol, Acta Cryst, Section E 2016, 72(8), 1093-1098.

- Remy, R.; Bochet, C.G. The Arene-Alkene Cycloaddition, Chem. Rev. 2016, 116, 9816-9849.

- Dennison, G.H.; Bochet, C.G.; Curty, C.; Ducry, J.; Nielsen, D.J.; Sambrook, M.R.; Zaugg, A.; Johnston, M. R., Supramolecular Agent-Simulant Correlations for the Luminescence Based Detection of V-Series Chemical Warfare Agents with Trivalent Lanthanide Complexes, Eur. J. Inorg. Chem. 2016, 9, 1348-1358.

- C.G. Bochet, Probing mechanisms of photochemical reactions: how to teach a young dog old tricks, Chimia 2016, 70, 182-185.

- Janett, E.; Bernardinelli, Y.; Müller, D.; Bochet, C.G. Synthesis of FMRFaNV, a photoreleasable caged transmitter designed to study neurons-glia interactions in the central nervous system, Bioconjugate Chemistry 2015, 26, 2408-2418.

- Chetioui, S.; Hamdouni, N.; Bochet, C G.; Djukic, J.P.; Bailly, C., Crystal structure of bis{μ-1-[(E)-(3-methoxyphenyl)diazenyl]naphthalen-2-olato-κ3N2,O:O}bis({1-[(E)-(3-methoxyphenyl)diazenyl]naphthalen-2-olato-κ2N2,O}copper(II)), Acta Cryst, Section E 2015, 71(12), 211-212.

- Anstaett, P.; Leonidova, A.; Janett, E.; Bochet, C. G.; Gasser, G., Reply to the Commentary by Trentham et al. on “Caged Phosphate and the Slips and Misses in Determination of Quantum Yields for Ultraviolet-A-Induced Photouncaging” by Gasser and Co-Workers, ChemPhysChem 2015, 16, 1863-1866.

- Ndongo, J. T.; Issa, M. E; Messi, A. N.; Ngo Mbing, J.; Cuendet, M.; Pegnyemb, D. E.; Bochet, C. G.; Cytotoxic flavonoid and other constituents from the stem bark of Ochna schweinfurthiana, Nat. Prod. Res. 2015, 29(17), 1684-1687.

- Bernardinelli, Y.; Randall, J.; Janett, E.; Nikonenko, I.; König, S.; Jones, E. V.; Flores, C. E.; Murai, K. K.; Bochet, C. G.; Holtmaat, A.; Muller, D., Activity-Dependent Structural Plasticity of Perisynaptic Astrocytic Domains Promotes Excitatory Synapse Stability, Current Biology 2014, 24(15), 1679-1688.

- Zimmermann, M.; Cal, R.; Janett, E.; Hoffmann, V.; Bochet, C. G.; Constable, E.; Beaufils, F.; Wymann, M. P. Angew. Chem. Int. Ed. 2014, 53, 4717–4720.

- T. Solomek, C.G. Bochet, T. Bally, The Primary Steps in Excited State Hydrogen Transfer: The Phototautomerization of o-Nitrobenzyl Derivatives, Chem. Eur. J. 2014, 20, 8062-8067.

- C.G. Bochet, Towards a photochemical synthesis of peptides, Chimia 2013, 67, 896-898.

- U. Streit, F. Birbaum, A. Quattropani, CG. Bochet, The photocycloaddition of arenes and allenes. J. Org. Chem. 2013, 78, 6890-6910.

- A. Crochet, I. Alimi, C.G. Bochet, K.M. Fromm, Acta Crystallographica Sect. E, 2013, E69, o339.

- R. Remy, I. Alimi, C.G. Bochet, Photochemical generation of indole libraries, Submitted for publication.

- C.G. Bochet, Organic Photochemistry, in Comprehensive Organic Synthesis II, G. Molander, P. Knochel, C. Welch Eds, Elsevier, 2014.

- Klan, P.; Solomek, T.; Bochet, C. G.; Blanc, A.; Givens, R.; Rubina, M.; Popik, V.; Kostikov, A.; Wirz, J. Photoremovable Protecting Groups in Chemistry and Biology: Reaction Mechanisms and Efficacy, Chem. Rev. 2013, 113, 119-191.

- T. Solomek, S. Mercier, T. Bally, C.G. Bochet, Photolysis of ortho-nitrobenzylic derivatives: the importance of the leaving group, Photochem. Photobiol. Sci. 2012, 11, 548-555.

- J.L. Débieux, C.G. Bochet, The all-photochemical synthesis of an OGP(10-14) precursor, Chem. Sci. 2012, 3, 405-406.

- C.G. Bochet, A. Blanc, Photolabile protecting groups in organic synthesis, in 2010 CRC Handbook of photochemistry and photobiology, A. Griesbeck, M. Oelgemoeller, Eds, Taylor and Francis 2011.

- N. Charbonnet, E. Riguet, C. G. Bochet, Singlet oxygen-induced rearrangement of furan derivatives, Synlett, 2011, 2231-2233.

- V. San Miguel Arnanz, C. G. Bochet, A. del Campo, Wavelength selective caged surfaces: how many functional levels are possible? J. Am. Chem. Soc. 2011, 133, 5380-5388.

- U. Streit, C. G. Bochet, The arene-alkene photocycloaddition, Beilstein Journal of Organic Chemistry, 2011, 7, 525-542.

- H. Haning, C.G. Mañas, V. Paddock, C.G. Bochet, A.J.P. White, G. Bernardinelli, I. Mann, W. Oppolzer, A.C. Spivey, Total Synthesis of the Amaryllicaceae Alkaloid Clivonine, Org. Biomol. Chem. 2011, 9, 2809-2820.

-  T. Jack, J. Simonin, S. Singhanat, C. G. Bochet, “Unconventional Methods in Organic Synthesis”, 41th CUSO Summer School in Organic Chemistry. Chimia 2011, 65, 97-99.

- C.G. Mañas, V. Paddock, C.G. Bochet, A.C. Spivey, A.J.P. White, I. Mann, W. Oppolzer, Total Synthesis of the Lycorenine-type Amaryllicaceae Alkaloid (+/-)-Clivonine via a Biomimetic Ring-switch from a Lycorine-type Progenitor, J. Am. Chem. Soc. 2010, 132, 5176-5178.

- J.L. Débieux, C.G. Bochet, Photoinduced acyl transfer, J. Phys. Org. Chem. 2010, 23, 272-282.

- C.G. Bochet, Hard work and light experience: early steps in photochemistry, Chimia 2009, 63, 872-874

- C.G. Bochet, T. Draper, B. Bocquet, M.T. Pope, A.F. Williams, 182Tungsten Mössbauer spectroscopy of heteropolytungstates, Dalton Trans. 2009, 5127-5131.

- J.L. Débieux, C.G. Bochet, Preparation of photoactivable amino acid derivatives, J. Org. Chem. 2009, 74, 4519-4524.

- C.G. Bochet, A. Blanc, Photolabile protecting groups in organic synthesis, in Handbook of preparative photochemistry, Angelo Albini, Ed., John Wiley 2009, in press.

- F.L. Stefanato, E. Abou-Mansour, A. Buchala, M. Kretschmer, A. Mosbach, M. Hahn, C.G. Bochet, J-P. Métraux, H.J. Schoonbeek, The ABC-transporter BcatrB protects Botrytis cinerea against camalexin and is a virulence factor on Arabidopsis thaliana, The Plant Journal 2009, 58(3), 499-510.

- S. Mercier, C.G. Bochet, Photolabile linkers units, in Linker Strategies in Solid-Phase Organic Synthesis, Peter Scott, Ed., John Wiley 2009.

- U. Streit, C.G. Bochet, Recent advances in arene photocycloadditions, Chimia 2008, 62, 962-966.

- F. Birbaum, A. Neels, C.G. Bochet, The photochemistry of allenyl salicylaldehydes, Org. Lett. 2008, 10, 3175-3178.

- J. Haesler, I. Schindelholz, E. Riguet, C.G. Bochet, W. Hug, Absolute Configuration of Chirally Deuterated Neopentane, Nature 2007, 446 , 526-529.

- E. Riguet, C.G. Bochet, A new safety-catch photolabile protecting group, Org. Lett. 2007 , 9 , 5453-5456.

- C.-L. Ciana, C.G. Bochet, Clean and Easy Photochemistry, Chimia 2007 , 650-654.

- J.L. Débieux, A. Cosandey, C. Helgen, C.G. Bochet, Photoacylation of alcohols in neutral medium, Eur. J. Org. Chem . 2007, 2073-2077.

- A. Blanc, C.G. Bochet, Isotope Effects in Photochemistry. 2. Application to Chromatic Orthogonality , Organic Letters 2007, 9 , 2649-2651.

- C. Helgen, C.G. Bochet, Photoacylation of amines with new heterocycles, Heterocycles 2006 , 67(2) , 797-805.

- C.G. Bochet, Photochemical release of various functional groups, Pure & Appl. Chem. 2006 , 78(2) , 241-247.

- J. Lage Robles, C.G. Bochet, Photochemical liberation of aldehydes, Org. Lett. 2005 , 7 , 3545-3547.

- A.D. Cohen, C. Helgen, C.G. Bochet, J.P. Toscano, The Mechanism of Photoinduced Acylation of Amines by N-Acyl-5,7-dinitroindoline as Determined by TRIR Spectroscopy, Org. Lett. 2005 , 7 , 2845-2847.

- V. Tamilmani, C.A. Daul, J. Lage Robles, C.G. Bochet, P. Venuvanalingam, Hydrogen Bond Stabilization in Diels-Alder Transition States. The Cycloaddition of hydroxy-ortho-quinodimethane with Fumaric acid and Dimethylfumarate. Chem. Phys. Lett. 2005 , 406 , 355-359 .

- C.G. Bochet, Photochemical activation of functional groups, in Advances in Organic Synthesis, G. Jenner, Ed., 2005 , 1 , 3-23.

- V. Fluxa, T.A. Jenny, C.G. Bochet, Determination of tetrasubstituted alkene geometry by proton NMR, Tetrahedron Lett. 2005 , 46 , 3793-3795.

- C.G. Bochet, Chromatic orthogonality in organic synthesis, Synlett 2004 , 2268-2274.

- A. Blanc, C.G. Bochet, Isotope Effects in Photochemistry. 1. o -Nitrobenzyl alcohol derivatives, J. Am. Chem. Soc., 2004 , 126 , 7174-7175.

- M. Kessler, R. Glatthar, B. Giese, C.G. Bochet, Orthogonal Photocleavable Protecting Groups in Solid Phase Synthesis, Org. Lett. 2003 , 5 , 1179-1181.

- A. Blanc, C.G. Bochet, Bis-(o-nitrophenyl)-ethanediol: a practical photolabile protecting group for ketones and aldehydes, J. Org. Chem, 2003 , 68 , 1138-1141.

- K.M. Fromm, E.D. Gueneau, H. Goesmann, C.G. Bochet, One-dimensional water" and "one-dimensional acid" as new proton conducting material in analogy to biological water channels? Synthesis and the unique crystal structure of 1 ? [(H 2 O) Ì (DB18C6)( m 2 -H 2 O) 2/2 ] 1 ? [(H 3 O) Ì (DB18C6)( m 2 -H 2 O) 2/2 ]I 3 (DB18C6 = dibenzo-18-crown-6), Z. Anorg. Allg. Chem. 2003 ,629 , 597-600 .

- C. Helgen, C.G. Bochet, Photochemical Protection of Amines with the Cbz Group, J. Org. Chem, 2003 , 68 , 2483-2486 .

- A. Blanc, C.G. Bochet, Wavelength-controlled orthogonal photolysis of protecting groups, J. Org. Chem, 2002 , 67 , 5567-5577.

- C.G. Bochet, Photolabile protecting groups and linkers, J. Chem. Soc., Perkin Trans. I 2002 , 125-152 .

- C. Helgen, C.G. Bochet, Preparation of Secondary and Tertiary Amides under Neutral Conditions by Photochemical Acylation of Amines, Synlett 2001 , 1968-1970.

- C.G. Bochet, Selective Synthesis, New Reagents for Specific Transformations, Champéry, June 6-9, 2001, Chimia 2001 , 55 , 732-736 .

- C.G. Bochet, Orthogonal Photolysis of Protecting Groups. Angew. Chem. Int. Ed. Engl. 2001 , 40 , 2071-2073.

- D. D'Addona, C.G. Bochet, Preparation of carbamates from alcohols and amines under mild conditions, Tetrahedron Lett. 2001 , 42, 5227-5229.

- C.G. Bochet, Wavelength-selective Cleavage of Photolabile Protecting Groups. Tetrahedron Lett. 2000 , 41 , 6341-6346.

- W. Oppolzer, C.G. Bochet, Asymmetric synthesis of the spirocyclic core of the Cylindricine-type alkaloids. Tetrahedron: Asymmetry 2000 , 11 , 4761-4770.

- C. Edder, C. Piguet, G. Bernardinelli, J. Mareda, C.G. Bochet, J.C.G. Bünzli, G. Hopfgartner, Control of Thermodynamic Selectivity and Fine Tuning of Iron(II) Spin-crossover Equilibria in Self-assembled Non-covalent Heterodimetallic d-f Podates: Unusual Electronic Effects of Electro-withdrawing Sulfonamide Groups. Inorg. Chem, 2000 , 39 , 5059-5073 .

- C. G. Bochet, 35th ESF/EUCHEM Conference on Stereochemistry, Chimia 2000 , 54 , 472-477.

- B.M. Trost, T.L. Calkins, C.G. Bochet, A concise convergent synthesis of (+)-Parviflorin, (+)-Squamocin K and (+)-5 S -hydroxyparviflorin. Angew. Chem. Int. Ed. Engl. 1997 , 36 , 2632-2635.

- C.G. Bochet, Synthèse asymétrique d'alcaloïdes par hydroxyamination électrophile d'énolates chiraux. Première synthèse totale de la (+)-Trianthine. Université de Genève, Thèse N° 2836, 1996 .

- W. Oppolzer, C.G. Bochet, Enantioselective Preparation and Hydroboration of Cyclic Enamides: Synthesis of (2S)-Pseudoconhydrine, Tetrahedron Lett. 1995 , 36 , 2959-2962.

- C. Piguet, J.C.G. Bünzli, G. Bernardinelli, C.G. Bochet, P. Froidevaux, Design of Luminescent Building Blocks for Supramolecular Triple-Helical Lanthanide Complexes, J. Chem. Soc., Dalton Trans. 1995 , 83-97.

- W. Oppolzer, C.G. Bochet, E. Merifield, Diastereo- and Enantioselective Syntheses of (-)-Coniine, (-)-Solenopsin A, (-)-Solenopsis fugax venom and (-)-Xenovenine via Deoxygenative Decarboxylation of 2-Carbonylsultam-Substituted N-Hydroxy-Piperidines and Pyrrolidines, Tetrahedron Letters 1994 , 35 , 7015-7018.

- W. Oppolzer, A.C. Spivey, C.G. Bochet, Suprafaciality of Thermal N -4-Alkenylhydroxylamine Cyclizations: Syntheses of (±)- a -Lycorane and (+)-Trianthine, J. Am. Chem. Soc. 1994 , 116, 3139-3140.

- C.G. Bochet, C. Piguet, A.F. Williams, Synthesis and Electronic Properties of Intensely Coloured Iron(II) Complexes with New 4-Substituted Planar Tridentate Nitrogen Ligands Analogous to 2,2':6',2"-Terpyridine, Helv. Chim. Acta 1993 , 76 , 372-384.
Updated on Oct 17, 2018